RELEVANT FRAGMENT CAPTURE
AMP based target enrichment preferentially enriches for highly fragmented ctDNA over genomic cell-free DNA (cDNA) to reduce background noise and increase detection sensitivity of low allelic frequency (AF) mutations.
SINGLE-DAY LIBRARY PREP
NGS- ready libraries can be prepared in under 8 hours with less than 1 hour of hands-on time, providing sequencing results in as little as 3 days.
ERROR CORRECTION & QUANTITATIVE ANALYSIS
molecular bar coded adapters ligated prior to amplification enable duplicate read binning and advance error correction for confident variant calls
SENSITIVE & ROBUST VARIANT DETECTION
reliably detect high AF (5%) variants using as little as 5ng total ctDNA input and low AF (1%) variants from as little as 10ng