Reagents
Fluorescent In Vivo Imaging Agents
Whether you are studying cancer biology, tracking stem cells or monitoring infections, PerkinElmer’s comprehensive suite of in vivo imaging reagents enables unmatched imaging of a broad-range of disease-related biomarkers and pathways for your research. Our optical reagents, labeling kits and dyes have been optimized on our IVIS® in vivo imaging platform. In addition to our optical imaging reagents, we offer radio imaging nuclides for PET imaging studies.
• Fluorescent agents, Dyes, Labeling Kits, and Nanoparticles
• Bioluminescent oncology cell lines and bacteria created using luciferase (luc2) vector for utlra brite sensitivity
• Bioluminescent substrates including D-Luciferin K+ salt and RediJect Luciferin in ready-touse injectable format
• Radio imaging nuclides
Activable Fluorescent Agents
Part Number Fluorescent Probe Biological Target
770504 XenoLight RediJect D-Luciferin **Pre-formulated bioluminescent substrate ready for use
in in vivo imaging with Firefly Luciferase
NEV10723EX AngioSense 680EX *Vascular probe: Leaks into sites of edema/cancer
NEV10878 IntegriSense 750* αVβ3 integrin targeted probe: Marker on tumors,
neovasculature, and osteoclasts
NEV10932 MMPSense 750 FAST* Pan-MMP activatable probe: Secreted marker of
inflammatory cells, fibrosis, and tumor margins.
NEV10972EX ProSense 750EX* Pan-cathepsin activatable probe: Lysosomal marker of
inflammatory cells and tumor cells.
Specifications
Optical Imaging Classification Bioluminescence imaging, Fluorescence Imaging
Quantity in a Package Amount 5.0 Units
Shipping Condition Blue Ice
Unit Size 1 vial
Targeted Fluorescent Agents
Activatable agents are optically silent upon injection but are activated in vivo through cleavage by specific protease biomarkers of disease. Benefits include biologically specific readouts and high signal-to-noise at the target biology. The FAST platform represents the next generation of agents from PerkinElmer. Utilizing a novel small molecule design, the FAST agents offer improved specificity, accelerated activation profile and earlier imaging timepoints.
Optimized in vivo imaging agents that actively target and bind to specific biomarkers. Benefits include the agents’ highly specific targeting to key biologies.
Product Product Description Catalog Number
Annexin-Vivo 750 In vivo targeting of membrane-bound NEV11053
phosphatidylserine exposed during the early
stages of apoptosis
BacteriSense 645 Fast-clearing, targeted probe which NEV10080
binds to negatively charged lipids on the
bacterial cell membrane, enabling the monitoring
of infection progression in real time.
FolateRSense 680 Highly specific and sensitive in detection NEV10040
of Folate Receptor protein. Can be used to
closely monitor and quantitate tumor growth and
metabolism.
Vascular and Physiological Fluorescent Agents
PerkinElmer’s vascular and physiological agents are a range of highly fluorescent in vivo imaging molecules that remain highly stable and localized in the anatomy for various periods of time to enable imaging of disease physiology, vasculature, vascular permeability and angiogenesis.
Product Product Description Catalog Number
AngioSense 680 EX Imaging of vascularity, perfusion and NEV10054EX
AngioSense 750 EX vascular permeability. Remains locali NEV10011EX
-zed in vasculature for 0-4 h; accumul
-ates in tumors and arthritic joints at 24
AngioSPARK 680 -h. Imaging of vascularity, perfusion and NEV10149
vascular permeability; long pharmaco NEV10150
GastroSense 750 -kinetic profile. Imaging to monitor gas NEV11121
-tric emptying and the impact of various
drugs on gastric motility; may also be
used as an anatomical marker for the
stomach.
Genhance 680 (1 mg) Small molecule fluorescence agent. Use NEV10117
Genhance 680 (5 mg) as a control or in vascular permeability NEV10130
Genhance 750 (1 mg) imaging. NEV10118
Genhance 750 (5 mg) NEV10177
Superhance 680 Imaging of vascularity, perfusion and vas NEV10116
-cular permeability; short pharmacokinetic
profile.